Alzheimer"s Inhibitor Solanezumab Testing in the UK - http://clapway.com/2015/07/26/alzheimers-inhibitor-solanezumab-testing-in-the-uk567/

In the aftermath of the pharmaceutical company Eli Lilly’s announcement that their drug Solanezumab may actually inhibit memory loss in people with Alzheimer’s, several authoritative scientists called for more testing, and it seems that there may be contention on what constitutes an effectual test population.

WAIT, WHAT WAS WRONG WITH SOLANEZUMAB?

Researchers have widely acknowledged the benefits of Solanezumab, since it is literally the first drug to have proved to actually slow the effects of Alzheimer’s disease on the brain. Many other scientists, however, contest these findings, claiming that Solanezumab was only tested on individuals who had already manifested symptoms of Alzheimer’s and therefore have already shown decreased brain function. Currently, scientists are trying to get Eli Lilly to come up with a way to develop the drug such that it helps those already predisposed to the disease.

“Reliable and relatively inexpensive disease predictive markers are urgently needed, whether these be blood, imaging or psychologically based to see whether they really do what it says on the label,” remarked Professor Mann of Manchester University.

STATUS OF ALZHEIMER’S RESEARCH

Meanwhile, the director of research for Alzheimer’s Research UK added that current diagnostic measure used to detect the disease must be improved, because “25% of diagnoses by doctors of early-stage Alzheimer’s are incorrect…Obviously that figure has to improve. Indeed, we have to develop tests that will allow us to make accurate diagnoses at even earlier stages of the disease, before there has been a loss of brain function.”

Despite researchers’ not knowing how the diagnosis method can be improved, Karran suggested that new imaging techniques will probably give the greatest boon to the detection of early-stage Alzheimer’s. “However, these techniques are currently expensive–costs can reach £1,000 to £2,000 a scan,” Kurran warned. “On top of that, we still do not know how much the pharmaceuticals companies (sic) are going to charge for their anti-dementia drugs once we have learned how to pinpoint those who should receive them.”

HOW SOLANEZUMAB WORKS

Solanezumab binds “to specific, single molecules (called abeta) that aggregate to form amyloid in the brain,” and there it reacts in a way such that the disease’s symptoms, like disorientation, confusion and memory loss are delayed. “That may explain its ability to slow the disease in mid cases. In addition, there may be a natural loss of these small abeta molecules from amyloid plaques that would also be part of its therapeutic benefit,” opined Karran.

Many people, scientist, elderly, and both, are hopeful that future drugs will improve upon Solanezumab’s already impressive ability to combat the effects of Alzheimer’s.

“From a scientific perspective, this study is exciting because it further validates the amyloid hypothesis …and will therefore guide scientists working on more effective disease–modifying therapeutics,” concluded Dr. Tara Spires-Jones of Edinburgh University.

BITTERSWEET FUTURE

Roughly 225,000 people are currently diagnosed with Alzheimer’s in the United Kingdom, and that number is forecast to rise as the bulk in the present’s population ages. The masses are glad to accept anything with a shot at fighting the effects of Alzheimer’s.

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Alzheimer"s Inhibitor Solanezumab Testing in the UK

Over Fifty and Well Off? You Should Probably Cut Down on Drinking - http://clapway.com/2015/07/25/over-fifty-and-well-off-you-should-probably-cut-down-on-drinking654/

Whether you think success is an the individualist’s carrot to enjoy after a lifetime of thoughtful adaptation to an increasingly capricious market, or a fictitious stick specifically designed to drive you absolutely mad, heed this – if you’ve achieved equity, had a family (or perhaps chosen not to), and are basically capable of being a healthy, active and sociable fifty-something or older, it may be time for you to stop drinking, or perhaps ease off the drinks, per de rigueur de la classe.

STOP DRINKING? au CONTRAIRE MON CAPITAN

In a statistical study receiving 9,000 responses, researchers have concluded that over-drinking is a “middle class phenomenon,” that is possibly a major strand of social dissonance, causing unnecessary health and social destitution to an extent that really isn’t emotionally or psychologically necessary for an older person who’s already flourished.

To be more specific the study found that men in their early 60s had a higher rate of heavy drinking than all other ages over fifty. Conversely, instead of a latent peak, women’s risk for heavy drinking fell proportionately with age. This isn’t to imply that women *get it* earlier (because somehow, we already knew that).

WHY SHOULD THE SOON-TO-BE-AGED STOP DRINKING?

From the researchers’ study, it appears that the present’s golden-age population may be drinking more frequently, and in heavier doses than they have since they first became acquainted with drinking in college.

Additionally, greater income increases the chances for women over fifty to drink more. However, smoking, higher education diplomas, and fair health each significantly increase the risk of heavy drinking, for both the sexes.

WHY DO MEN HAVE IT EASIER?

When it comes to the risk of drinking, it actually doesn’t. Women’s drinking habits seem unaffected by the status of domestic partnership, but men who live alone are more likely to drink heavily, especially if they’re divorced or separated, especially if they’re caucasian.

MATERNAL INSTINCTS ARE A GOOD THING

Women responsible for others’ care tend to take care of themselves too, in this respect, lowering their likelihood to drink dangerously. In England, though, the researchers declared this phenomenon of increased likelihood for heavy drinking to be more of a “middle class phenomenon,” and so presumably something the fifty-somethings and older of the upper class does not have to be susceptible to. People over fifty in good health, with more income, higher educational diplomas and a generally more active social life are more likely to overdrink than simply stop drinking.

Researchers concluded that this will to alcoholism among those men and women over fifty is something associated with affluence, and the coveted “successful” aging process.

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Over Fifty and Well Off? You Should Probably Cut Down on Drinking

Global Climate Change: Perhaps the Graying Can Go Green - http://clapway.com/2015/07/12/global-climate-change-perhaps-the-graying-can-go-green-542/

The greatest bulk of the world’s population of humans is growing old, and this is happening during the greatest environmental crisis the Earth has experienced since humankind rose to power: global climate change.

NO NON-SEQUITURS FOR GLOBAL CLIMATE CHANGE

This is not rhetoric: the quantity of people over sixty years old has doubled since 1980, and this number is predicted to surpass two billion by the year 2050. In the first half of the 21st century, this population will bloat from 11 to 22 percent of the total human population. These are statistics formed by the World Trade Organization. They go on to report that, exclusively in the U.S., those over 60 accounted for 18% of the population, and this piece will grow to a quarter of the total population by the year 2050.

As for what climate change has to do with the aging population, we’re not here to simply blame this burgeoning population for spending their entire lives reveling in the kinds of excess that sealed the 21st century’s fate in a vain celebration of its own narcissistic addictions. No, we aren’t going to say this.

PRESIDENT OBAMA’S GOLDEN OPPORTUNITY

But President Obama will soon be hosting the White House Conference on Aging in Washington D.C., and he has yet to add the topic of climate change to the convention’s agenda. Many Americans believe this is a golden opportunity (pun intended) to expose this massive demographic to the most urgent social problem of our day. If he did add global climate change to the agenda, Obama would help increase political consensus regarding this ecological crisis before the U.N. Climate Change Conference in Paris convenes this fall.

BUSINESS AS USUAL IS RISKY AT BEST

Michael Bloomberg, Henry Paulson, and Tom Steyer formed a PR campaign called Risky Business last year. It’s composed of a bipartisan series of studies explicating the economic and health risks this nation faces, with each region of the country to its own, unique fate.

Their findings were universally negative, showing the economy sliding into a state of perpetual disruption, and health dangers increasing as the environment loses its ability to maintain a hospitable atmosphere, e.g., a southerner of ordinary means will have 1.5 to 4 more heat months per year, causing him or her to witness 14 to 45 more deaths per 100,000 people. The greatest amount of risk is endured by urban and elderly residents.

IT GETS WORSE

What this means is that, in addition to it being too late to change the world’s environmental course, we also need to start planning how to curb global climate change’s impact on American subpopulations. The ones most at risk are at once the largest homogeneous chunk and the most politically involved subpopulation in the United States. Older Americans tend to vote much more often and regularly than younger ones, e.g., in the 2012 presidential election, 71% of those 64 to 75 years old voted–much higher than the measly 38% of 18-24 year olds. In light of such facts, why shouldn’t Obama appeal to older adults to assist with the political struggle to adapt to global climate change?

It’s not as if it would be an outlying topic to the convention. The main theme includes such symbolically near associations as maintaining the elderly’s health. If Obama steps up, we won’t even have to do the math, here.

BUILDING A NEW climate change NARRATIVE FOR OLDER AMERICANS

What’s more, it’s common sense that the elderly are more concerned with their legacies, and about future generations’ well-being. Laura Cartstensen, director of the Stanford Center on Longevity said in a TED Talk that when an adults reach the middle of their life, their sense of time reverses. Instead of conceiving of one’s existence in terms of how much time has already passed, one begins to see themselves in terms of how much (or little) time is left to live.

Carstensen continues: “When we recognize that we don’t have all the time in the world, we see our priorities most clearly;” so perhaps concern for the prosperity of one’s family, and the world’s vital posterity can be synthesized into a potent narrative for those of us this aging citizenry is preparing to leave behind. Perhaps the graying can go green, after all.

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Global Climate Change: Perhaps the Graying Can Go Green