Showing posts with label gene. Show all posts
Showing posts with label gene. Show all posts

Sunday, August 23, 2015

This fascinating study on #HolocaustSurvivors shows us #epigenetic inheritance in the works! - http://clapway.com/2015/08/23/holocaust-trauma-can-be-genetically-inherited232/

According to a new study conducted by researchers at Mount Sinai Hospital, Holocaust survivors could have passed to their children the trauma they suffered from.


The research was published in the Biological Psychiatry Journal and it contains 32 tests on Jewish men and women who had been at concentration camps during the Holocaust, witnessed or experienced torture, or had to hide from the Nazis during World War II. After examination of the genes of 22 of their adult offspring, researchers compared them to Jewish families who did not experience any of the events in Europe during the Nazis’ rule.


The children of Holocaust survivors were found to be less likely to handle anxiety when exposed to a traumatic event and 3 times more like to develop post-traumatic stress than demographically similar Jewish people whose parents did not experience the Holocaust. Also, children of Holocaust survivors were found to have the same genetic changes  and abnormalities with their parents as well as with other people suffering post-traumatic stress disorder.


EVIDENCE OF THE EPIGENETIC INHERITANCE THEORY?


This is the first time that a research becomes an evidence to support the theory of epigenetic inheritance, according to which, environmental factors can alter the genes of offspring. In the past, a research showed that some chemical marks were able to pass to the next generation, but this is the first time we see life experiences of a person have an impact on future generations’ psychology.


The researchers though did not approach the study with psychological tests, as someone could suppose, but they focused on a gene which is affected by trauma and is known to be associated with the regulation of stress hormones. Both the survivors and their children showed epigenetic marks on the same part of that gene, which were not found of families who did not survive the Holocaust.


CHILDREN OF HOLOCAUST SURVIVORS STARTED THE STUDY


Dr. Yehuda, professor of Holocaust Studies at the Avraham Harman Institute of Contemporary Jewry at the Hebrew University of Jerusalem, says that after setting up a clinic for Holocaust survivors at Mount Sinai hospital, they started receiving phone calls not from the survivors themselves, but from their children.


“They talked about feeling traumatized by witnessing the symptoms of their parents. And they talked about being traumatized by some of the expectations that the Holocaust had placed on them, such as that they are the reason their parents survived and, therefore, there was a whole set of things that they would now have to accomplish so that all the people that died— they could give their lives meaning. They had difficulty in any kind of a separation circumstance — divorce and those kinds of things. And they described essentially this problem in separating from their parents,” he said.



 


For Clapway’s latest and best of the week, Brandi has summarized it all for you as follows:




Holocaust Trauma Can Be Genetically Inherited

Thursday, August 20, 2015

On #obesity, it might not be your fault. And scientists want to help you cure your #hereditary issue. - http://clapway.com/2015/08/20/scientists-discovered-how-obesity-works-to-treat-it-324/

The key gene connected to obesity, responsible for people getting fatter, has finally been figured out. Scientists anticipate this to offer a totally new approach to the problem. It seems like a strict diet and intensive workouts will no longer be the only solutions to obesity, whose mysteries have just been solved.


THE FTO OBESITY GENE


In 2007, researchers found out that there was a gene that was somehow related to obesity, but they were not able to connect it to appetite and other factors. However, now we know that the FTO gene has an evil, faulty version that stores energy from food as fat, and does not let it get burnt.  What the experiments show is quite positive, though, since tests on mice and human cells indicate that this can be reversed and the hope of a drug or other treatment might be developed.


Responsible for this research are scientists from Harvard University and MIT, who published their study online on Wednesday on  the New England Journal of Medicine.


OBESITY IS NOT ALL ABOUT EATING


Melina Slaussnitzer, lead author of the study and genetics specialist at Harvard-affiliated Beth Israel Deaconess Medical Center, says that this discovery is an answer to those who believe that obesity is a choice: “For the first time, genetics has revealed a mechanism in obesity that was not really suspected before,” she says.


Related Post: Vitamin D Pills May Be Dangerous for Teenagers


Dr. Clifforf Rosen, associate editor at the medical journal and scientist at Maine Medical Center Research Institute, says that “it’s a big deal,” and that obesity is not all about eating, but how the FTO gene decides to store energy and use food. With this discovery, “you now have a pathway for drugs that can make those fat cells work differently,” he continued.


BUT THERE IS NO MAGIC PILL


So far, there has not been an obesity drug that would fight the problem long-term targeting metabolism. Most of them just aim at the brain and affect appetite in many different ways, but scientists are positive that this is going to change. Even though we cannot guess how long it might take before a new drug based on the new data becomes available, they say that it will not be something like a magic pill. People will not be able to eat whatever they want without gaining weight and targeting fat pathway could affect other things.


Eating habits and exercise are still important since the gene glitch does not explain all obesity. Actually, FTO was found in 44 percent of Europeans but only 5 percent of blacks suggesting that there are other genes at work, as well.


Manolis Kellis, MIT professor, says that having the glitch doesn’t make you doomed to become obese but may predispose you to it: “People with two faulty copies of the gene (one from Mom and one from Dad) weighed an average of 7 pounds more than those without them. But some were a lot heavier than that, and 7 pounds can be the difference between a healthy and an unhealthy weight.”


A CURE IS ON THE WAY


With more than half a billion obese people in the world, the necessity of a drug which can hit obesity in its nucleus is getting bigger and bigger. The experiments, as the journal describes, anyway, show that scientists are already getting close to creating a new pill that will change the way experts fight obesity and the diseases it hosts.



 


Need some ways to lose weight? Consider Thin Ice:




Scientists Discovered How Obesity Works to Treat It