Hmm...apparently, there"s a #diabetes drug that can help with #weightloss in obese patients. - http://clapway.com/2015/08/20/liraglutide%e2%8e%afa-diabetes-drug-that-could-also-help-in-weight-loss-for-patients123/

A high dose of the diabetes drug, liraglutide, was associated with a 6% weight loss of in obese patients with type2 diabetes.

The clinical trial of liraglutide in obese diabetic patients

Liraglutide is a drug prescribed for diabetes management; it stimulates insulin release by binding to the target of an endogenous metabolic hormone. It was developed by Novo Nordisk and marketed under the name Victoza for the lower dose (up to 1.8 milligrams a day). The FDA approved a higher dose of liraglutide (3 milligrams per day) for weight loss only; it is sold under the brand name Saxenda.

The trial tested both low and high doses of liraglutide

A weight loss of even 5-10% could significantly change the outlook for diabetes patients and lower the risks of comorbidities. The researchers were therefore interested in the possibility of how the weight-loss dose of liraglutide could help reduce weight along with blood sugar levels. The trial looked at the effects of both low- and high-dose liraglutide on obese patients with type 2 diabetes. Of the 846 patients enrolled in the study, 423 were randomly assigned to the high dose (3 mg) group, 211 to the low dose (1.8 mg) group, and 212 participants received placebos. Additionally, the participants were also put on a calorie reduction and exercise regimen.

High dose liraglutide causes weight loss in diabetes patients

At the end of the follow-up period, high dose liraglutide resulted in a 6% weight loss, whereas the low dose showed 4.7% and the placebo, a 2% weight loss. Weight loss of more than 5% was seen in 54.3% of the patients as opposed to 40.4% and 21.4% in the patients who received the low dose drug and the placebo respectively. A weight loss of more than 10% was seen in 25.2% of patients who received the high dose liraglutide. Patients who received low dose liraglutide and the placebo had weight loss of more than ten percent in 15.9% and 6.7% of the cases respectively.

High-dose liraglutide is a good choice for obese diabetic patients because it shows better weight loss and sugar reduction than the currently accepted dosage. These results could help push for approval of the higher dose for diabetes management, and hopefully result in insurance coverage of this expensive drug.

Scientists have finally figured out how obesity works

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Liraglutide⎯a Diabetes Drug That Could Also Help in Weight Loss for Patients

On #obesity, it might not be your fault. And scientists want to help you cure your #hereditary issue. - http://clapway.com/2015/08/20/scientists-discovered-how-obesity-works-to-treat-it-324/

The key gene connected to obesity, responsible for people getting fatter, has finally been figured out. Scientists anticipate this to offer a totally new approach to the problem. It seems like a strict diet and intensive workouts will no longer be the only solutions to obesity, whose mysteries have just been solved.

THE FTO OBESITY GENE

In 2007, researchers found out that there was a gene that was somehow related to obesity, but they were not able to connect it to appetite and other factors. However, now we know that the FTO gene has an evil, faulty version that stores energy from food as fat, and does not let it get burnt.  What the experiments show is quite positive, though, since tests on mice and human cells indicate that this can be reversed and the hope of a drug or other treatment might be developed.

Responsible for this research are scientists from Harvard University and MIT, who published their study online on Wednesday on  the New England Journal of Medicine.

OBESITY IS NOT ALL ABOUT EATING

Melina Slaussnitzer, lead author of the study and genetics specialist at Harvard-affiliated Beth Israel Deaconess Medical Center, says that this discovery is an answer to those who believe that obesity is a choice: “For the first time, genetics has revealed a mechanism in obesity that was not really suspected before,” she says.

Related Post: Vitamin D Pills May Be Dangerous for Teenagers

Dr. Clifforf Rosen, associate editor at the medical journal and scientist at Maine Medical Center Research Institute, says that “it’s a big deal,” and that obesity is not all about eating, but how the FTO gene decides to store energy and use food. With this discovery, “you now have a pathway for drugs that can make those fat cells work differently,” he continued.

BUT THERE IS NO MAGIC PILL

So far, there has not been an obesity drug that would fight the problem long-term targeting metabolism. Most of them just aim at the brain and affect appetite in many different ways, but scientists are positive that this is going to change. Even though we cannot guess how long it might take before a new drug based on the new data becomes available, they say that it will not be something like a magic pill. People will not be able to eat whatever they want without gaining weight and targeting fat pathway could affect other things.

Eating habits and exercise are still important since the gene glitch does not explain all obesity. Actually, FTO was found in 44 percent of Europeans but only 5 percent of blacks suggesting that there are other genes at work, as well.

Manolis Kellis, MIT professor, says that having the glitch doesn’t make you doomed to become obese but may predispose you to it: “People with two faulty copies of the gene (one from Mom and one from Dad) weighed an average of 7 pounds more than those without them. But some were a lot heavier than that, and 7 pounds can be the difference between a healthy and an unhealthy weight.”

A CURE IS ON THE WAY

With more than half a billion obese people in the world, the necessity of a drug which can hit obesity in its nucleus is getting bigger and bigger. The experiments, as the journal describes, anyway, show that scientists are already getting close to creating a new pill that will change the way experts fight obesity and the diseases it hosts.

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Scientists Discovered How Obesity Works to Treat It

%VitaminD pills are quite popular, but scientists suggest that providing #obeseteenagers with many of them may have adverse consequences.% - http://clapway.com/2015/08/16/vitamin-d-pills-dangerous-teenagers-101/

Vitamin D pills are quite popular, but scientists suggest that providing obese teenagers with many of them may have adverse consequences. The new research of Mayo Clinic Children’s Center on childhood obesity advises that vitamin D pills may elevate adolescents’ cholesterol and fat-storing triglycerides levels.

VITAMIN D IS NOT THAT BENEFICIAL. YET.

Dr. Seema Kumar, a pediatric endocrinologist from Mayo Clinic, has been studying the effects of vitamin D for 10 years, but recently she came up with a discouraging conclusion:

“After three months of having vitamin D boosted into the normal range with supplements, these teenagers showed no changes in body weight, body mass index, waistline, blood pressure or blood flow,” she says, “We are not saying the links between vitamin D deficiency and chronic diseases do not exist for children – we just haven’t found any yet.”

VITAMIN D PILLS ARE NOT SLIMMING

While teenage obesity has quadrupled in the past thirty years, many studies indicate that vitamin D deficiency can lead to a series of weight-related medical complications. As a result, worried parents and providers increase the recommended daily intake, in an attempt to fight the clinical complications associated with obesity.

Dr. Kumar, however, notes that the pills’ popularity as a homeopathic weapon against obesity is what made her want to study their effects on overweight teenagers, a population at increased risk for chronic disease.

BE CAREFUL WITH THE INTAKE

Dr. Seema Kumar says that she is surprised that she and her team haven’t found more health benefits, but she made clear that, while vitamin D supplements at reasonable doses are not harmful at all, their usefulness for improving overall health in adolescents is still not clear.

Also, if you ingest too much vitamin D, you will suffer from  a condition called hypervitaminosis, which can result in poor appetite, nausea, vomiting or even kidney complications.

BEFORE YOU SLOW YOUR PILL INTAKE, MOMENTO, THIS WEEK:

Vitamin D Pills May Be Dangerous for Teenagers